Impact of Vitamin D3 Supplementation on Recurrent Aphthous Ulcer

Vitamin D is a well-known secosteroid hormone, which exerts multiple essential roles in bone physiology, cell growth and differentiation, the neuromuscular system, immunomodulatory functions autoimmune diseases. Deficiency of vitamin has been linked to many oral disorders including tooth decay, periodontitis, cancer, candidiasis, lichen planus recurrent aphthous ulcers. Many studies have revealed significant lower serum level ulcer patients compared with healthy volunteers. This proposes that supplementation may reduce severity lesion. To evaluate efficacy D3 replacement on objective study. study involved 65 idiopathic minor deficiency/insufficiency. These received supplement over 1 y. Severity disease was delineated by duration episodes, number ulcers per attack frequency recurrence. parameters were before after intake. In addition, 25-hydroxy concentrations measured administration enzyme-linked immunosorbent assay technique. We found decrease attacks each p-value<0.05 following replacement. Moreover, highly lowering episodes detected p-value<0.001. Gender specific analysis showed no statistically significance regarding at any point stages. Correlation only detectable correlation between baseline correction. safe positive impact improving regards lesions, recurrence who